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Both of these compounds work well by themselves but make a powerful combination when used together. MSM is taken orally, and DMSO can be applied topically. Only apply DMSO after cleaning the area with a mild soap and water. Its ability to penetrate tissue can be used to carry other substances, so we want to make sure no foreign material like oil, dirt or cologne is on the area of application.


The anti-inflammatory properties of MSM are well documented by scientific research. It’s believed that MSM inhibits NF-kB, a protein complex involved in inflammatory responses in your body. It also reduces the production of cytokines such as tumor necrosis factor alpha (TNF-ɑ) and interleukin 6 (IL-6), which are signaling proteins linked to systemic inflammation. Additionally, MSM can increase levels of glutathione, a potent antioxidant produced by your body. For example, supplementing with MSM significantly reduced inflammation in mice with stomach ulcers by inhibiting the release of inflammatory cytokines including TNF-ɑ and IL-6, as well as increasing glutathione levels.

Another study in 40 physically active men showed that taking 3 grams of MSM before exhaustive exercise decreased the release of inflammatory cytokines and prevented the over-stress of immune cells, compared to a placebo.




DMSO reduces inflammation by several mechanisms. It is an antioxidant, a scavenger of the free radicals that gather at the site of injury. This capability has been observed in experiments with laboratory animals7 and in 150 ulcerative colitis patients in a double-blinded randomized study in Baghdad, Iraq.8 DMSO also stabilizes membranes and slows or stops leakage from injured cells.



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