Here's my observation on hand fatigue: when I first got my 650R and got it plated, I rode it to work one day. I noticed that by the time I got to work (only about 30 mi one-way) my hands and arms were really aching. But now (about 2500 miles and 3 years later), my hands are hardly effected, even after a 200-mile day. Only thing I can figure is that early-on, I think I was really gripping the bars tight, and now on the street and highway I just relax and go with the flow. Maybe some hand-fatigue is related to trying to grip the controls too tightly, vs keeping a light touch?? What do you think? Also, for me, I run pretty high gearing: 15/45, vs the factory's 14/48. So my highway cruise of 65-70 is only requiring maybe 4 grand from the engine, vs a factory-geared bike running maybe 5 grand at that speed. So whether I adjusted my riding habits to a more relaxed grip-hold, or my gearing yields lower vibes, or both, I'm not fatigued near as much as I used to be after a long day in the saddle. Now, as for BUTT-fatigue , that's another issue. Like I posted earlier, my next 650R upgrade is going to be tall seatfoam, stepped down a bit for make a larger seating surface to help avoid the dreaded monkey-butt on longer rides.