It's been a little over a year since I put Nuetech Tubliss on the front and rear of my 300XC, and shortly after that I put them on my YZ125 (18" rear). Both bikes are used for trail riding in a variety of conditions, with both mx tires and the occasional trials rear. Here's my review: CONS: 1. Regular maintenance is more of a hassle than standard tubes with rim locks. I find myself checking the inner and outer pressure every ride, and usually make small adjustments every time. I also feel more compelled to maintain rim strips, as an inner-bladder failure would be a big deal out on the trail. So far, I've either added layers, or outright replaced rim strips (tape), with each tire change due to spoke heads showing through. 2. Changing tires is also more of a hassle. When removing a tire, I find it hard to make sure the outer tire and inner red liner are separate from each other. My spoons keep wanting to grab both the outer and inner. When mounting a tire, I find it hard to get the rim inside of both beads as required by the Tubliss system. The piece of metal included with purchase that is used as a "shoe horn" helps a little. After about a dozen tire changes, it still takes me 2x longer than a traditional tube/tire. 3. They are expensive. I went with the recommended new tires on each install, which means roughly $150 per wheel. I've heard of people using used tires successfully, especially if they use tire sealant. Also expensive - after a tire does fail, it seems best to replace it rather than trust the plug/patch on another trail ride out into the middle of nowhere. I wouldn't feel the same way with a traditional set-up. Similarly, when I do flat I'm more likely to ride back to the trailhead on it (see PROS), which destroy$ the tire. 4. When used with a tire sealant such as Slime, tires aren't very repairable on the trail. Plugs don't want to stick, and a patch from the inside is out of the question. 5. An inner bladder failure on the trail would be a huge PITA. 6. Tire repair kits need to be rethought. I know people who tell me just to carry a 21" tube - but what about rim locks? I'd hate to go through the repair, only to rip a valve stem a few miles later. I'm still sorting-out what I carry, but the latest includes plugs and patches, but no tube. I've also stopped using Slime to make trail repairs more effective. PROS: 1. Lower pressures, longer tire life. I'm not good enough to notice lighter weight. 2. I have been able to ride-out 3 flats without destroying my rims. 3. No rim dings. Even with a totally flat rear (outer) on very rocky terrain. 4. With tire sealant, punctures aren't much of a concern - only tears or pinch flats. Yes, I listed more CONS than PROS. But overall, I'm happy and sticking with the Tubliss system for now.