16 might be hard to fit without getting rid of the case guard and trimming the chain slider. I run a 15 / 44 and that lets the bike top out at 98 mph right before the limiter (GPS indicated) Droning along at 65 mph is 6300 RPM with this ratio, and it seems happy enough doing it. Tight(er) back roads the bike lives between 6000 - 9000. Never into the limiter. It'll do that for 200 mi. a day.