Nothing that effects the legendary reliability of these bikes.
The frame is aluminium obviously, which makes working on the carb more difficult than the '06. If you don't mind the extra work it takes to work on the carb, its a non issue. There was much to do about weight centralization with that change. Some feel it, others don't.
The engine has different castings. The oil passages are internal as opposed to external like on the '03-'06 bikes. Also the oil sump is between the cases on the '07+ bikes and holds just over a quart. If you do frequent oil changes (100-200 miles), its a non issue.
The chain can rub on the subframe if it is a adjusted too loose or isn't squared up correctly. I put a piece of cut thick rubber hose in that general area of the subframe and I also started measuring the chain adjustment instead of relying on the markers. No more rubbing.
You should probably put anti sieze lube on the bolts that fasten the case guard to the engine, rad shrouds to the tank, and spark plug.
Grease every chassis bearing in that thing upon delivery. Apparently grease is in short supply in Japan