Blisters are caused by two factors. 1. Friction and 2. Moisture If you can reduce either one of these you will help your hands. The use of baby powder is one way of reducing moisture. I am surprised that no one mentioned the use of under arm ANTI persperant. I believe this is used widely. I cann't see where the rubber gloves would help. They would trap the sweat and this is not good. I like the underware gloves. They are very thin and help to eliminate friction and wick moisture away. Those early season ride can be hard on the paws. Good luck.